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Recent trends in Synchrotron-based X-ray diffraction and imaging in the biomedical field

Tuesday (09.05.2017)
15:10 - 15:30
Part of:



Advanced X-ray

sources offer a wide range of structural and spectroscopic techniques to

analyze biomaterials, biomolecules and bio-interfaces in contact to a

biological environment.


The high

brilliance of 3rd generation synchrotron-based X-ray sources permits

to spatially resolve one-to-one structure-property relationships in a micro- or

nanofocused X-ray beam, evolving nanoscience aspects in the biomedical field. By

means of X-ray reflectivity (XRR) measurements of liquid/solid interfaces it is

possible to obtain electron density profiles and to, e.g., identify if material

adsorbed or deposited grows as a homogeneous film or as islands. X-ray micro

and nano-tomography allows to image complex synthetic and naturally occurring

3D architectures covering several length scales down to nanometers. X-ray absorption spectroscopy

(XAS) and in particular X-ray absorption near edge structure (XANES)

provides chemical sensitivity and information on the local chemical

environment, whereas from X-ray protein crystallography, the atomic and conformational

arrangement of complex biomolecules can be extracted. The particular strength

of these X-ray based techniques is their rather good compatibility

with many in-situ or in-operando conditions, permitting to dynamically track a process

or reaction under close-to-real conditions.



NanoLab is a facility providing access to advanced nano-characterization,

nano-structuring and nano-synthesis techniques which are complementary to the

advanced X-ray techniques available at DESY’s light sources. Access to the advanced X-ray sources

at DESY in Hamburg for public-funded research is possible via the regular

proposal system and via the novel EU funded open access platform “Nanoscience

Foundries and Fine analysis” - NFFA-Europe - to carry out projects for

multidisciplinary research at the nano-scale.






Dr.-Ing. Thomas F. Keller
Deutsches Elektronen-Synchrotron DESY
Additional Authors:
  • Thomas F. Keller
    and Institute of Nanostructure and Solid State Physics (INF), University of Hamburg, Germany