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Lecture

Inspired by the sugar code: driving cell fate by neoglycosylated collagen-based biomaterials

Tuesday (09.05.2017)
12:00 - 12:20 Room Goethe III
Part of:


In the field of material design

for regenerative medicine, there is a need for tools that can drive cell fate,

in order to better understand and control the biological responses.

 

Carbohydrates play fundamental

roles in a plethora of biological processes [1] including cellular trafficking,

adhesion and migration, immunological responses, disease initiation and

progression. Moreover, in biological systems, many carbohydrate-protein

interactions occur at cellular interfaces.

 

Given the relevant role played

by carbohydrates, they appear as invaluable tools for the design of bioactivated

materials for regenerative medicine applications. In fact, when exposed at the material-cell

interface, they might be able to direct and control cell fate [2]. Different conjugation

techniques for material surface

covalent functionalization with specific glycan structures will be presented.

The results of the interaction between neoglycosylated materials and different

cell lines will be outlined, highlighting how glycans do drive their behaviour.

For example, neoglucosylated collagen matrices drive F11 neuroblastoma cells to

differentiation into active neurons, while different sialylated collagen

matrices [3] are able to modulate gene expression of mMSC toward chondrogenesis

or osteogenesis [4].

 

 

 

 

 

 

 

References

 

[1] Hudak, J.E.; Bertozzi,

C.R. Chem. Biol. 2014, 21, 16-37.

 

[2] Russo, L.; Cipolla, L. (2016). Glycomics: new challenges

and opportunities in regenerative medicine. Chemistry,

Eur. J. DOI: 10.1002/chem.201602156.

 

[3] Russo, L.;

Sgambato, A.; Lecchi, M.; Pastori, V.; Raspanti, M.; Natalello, A.; Doglia,

S.M.; Nicotra, F.; Cipolla, L. ACS Chem Neurosci. 2014, 5, 261-5.

 

[4] Sgambato, A.; Russo, L.; Montesi, M.; Panseri,

S.; Marcacci, M.; Caravà, E.; Raspanti, M.; Cipolla, L. ACS Appl. Mater.

Interfaces, ACS Appl. Mater. Interfaces, 2016, 8, 14952–14957.

 

 

 

Acknowledgments.

 

We gratefully acknowledge FA

2015  and the European Community's

programme under Grant Agreement number: 642028 —H2020-MSCA-ITN-2014 “NABBA”for financial support.

 

Speaker:
Dr. Laura Cipolla
University of Milano-Bicocca