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Oral Poster

Systematic post-operative clinical assessment of lumbar ventrolateral vertebroplasty in the large animal model sheep using a minimally-invasive approach

Tuesday (09.05.2017)
18:15 - 18:18
Part of:
Line-Up:
18:00 Oral Poster Fibrinogen Adsorption and Network Formation on Melt Drawn Isotactic Polybutene-1 Thin Films 1 Xiaoyuan Zhang
18:03 Oral Poster Characterization of biomaterials using AFM based fast nanoscale imaging and quantitative nanomechanical techniques 1 Dr. Tanja Neumann
18:06 Oral Poster Hydrothermal conversion of porous Ca carbonate biominerals into bioactive Ca phosphate materials: towards antibiotic and antiosteoporotic bone graft substitutes 1 Dr. Ingo Sethmann
18:09 Oral Poster Study on the retarding effect of phytic acid on the hydration of a brushite cement 1 Dr. Katrin Hurle
18:12 Oral Poster Synthesis of hollow mesoporous bioactive glass nanoparticles with uniform size and shape 1 Kai Zheng
18:15 Oral Poster Systematic post-operative clinical assessment of lumbar ventrolateral vertebroplasty in the large animal model sheep using a minimally-invasive approach 1 Francesca Gunnella
18:18 Oral Poster Dual setting system – characterization of PEG-based-hydrogel/brushite composites for biomedical application 1 Michaela Rödel
18:21 Oral Poster The effect of HAc etching on the degradation behaviour of Mg-5Gd 1 Dr. Frank Feyerabend
18:24 Oral Poster Degradation behavior of as cast and powder metallurgy processed Mg-Ca alloys 0 Dipl.-Ing. Eshwara Phani Shubhakar Nidadavolu
18:27 Oral Poster Bio-inspired high-performance green biopolymer fibers 1 Dr. Hendrik Bargel
18:30 Oral Poster Diatom Biosilica for Catalytic and Adsorptive Applications 1 Cathleen Fischer
18:33 Oral Poster Gallotannin polyphenol enhancement of biomimetic enzymatic hydrogel mineralization 1 Dr. Timothy E.L. Douglas
18:36 Oral Poster Starch in textile application: Modification, processing and product development 1 Pavan Kumar Manvi
18:39 Oral Poster Recombinant Spider Silk Proteins Used as Biomedical Coating Material 1 Christian Borkner
18:42 Oral Poster Effects of cross-linking modifications on Collagen: a preliminary biological evaluation 1 Dr. Mattia Vacchini
18:45 Oral Poster Endothelialization of polymethylpentene fibers as a step towards patient-specific medical devices 1 M.Sc. Annika Wenz
18:48 Oral Poster Hybrid poly-lactide/gelatin electrospun scaffolds with controlled hydrophilicity and wettability. 1 Germano Piccirillo
18:51 Oral Poster Funktion and structure - Combined optical functionality and specific bio-interaction for multifunctional biomedical materials 1 Dr. Tina Sabel
18:57 Oral Poster Bacterial adhesion to PEEK compared to exemplary dental ceramic, metallic and composite materials 1 Dr. Lutz Scheideler
19:00 Oral Poster Attachment of Nanoparticle Drug-Release Systems on Shish-Kebab structured Poly(?-Caprolactone) Nanofibers 1 Dominik de Cassan
19:06 Oral Poster Improved Nanofleeces for Cell Culture Applications 1 Tobias Kürbitz

Session P.1: Oral Poster Session 1
Belongs to:
Topic P: Postersession


Introduction:

Representative pre-clinical studies, including the optimization of vertebroplastic/ kyphoplastic cement augmentation for vertebral body defects, should be performed in large animal models. This study aimed at the systematic characterization of an in vivo large animal model using strictly minimally-invasive, lumbar, ventrolateral vertebroplasty.

Methods:

Lumbar defects [diameter 5 mm; depth approx. 14 mm] were generated using a ventrolateral percutaneous approach in old, osteopenic, female sheep (40 Merino sheep; 6 – 9 years; 68 - 110 kg). L1 remained untouched, L2 contained an empty defect, and L3 a defect injected with a brushite-forming calcium phosphate cement (CPC). Trauma/functional impairment, surgical techniques, reproducibility, bone defects, cement filling, and functional cement augmentation were assessed by intraoperative incision-to-suture time and x-ray, postoperative trauma/impairment scores, and ex vivo osteodensitometry, micro-CT, histomorphometry, and biomechanical testing.

Results:

Minimally-invasive vertebroplasty showed a short operation time (28 ± 2 min; mean ± standard error of the mean) and x-ray exposure (1.59 ± 0.12 min), marginal local trauma (score 0.00 ± 0.00 at 24 h), fast postoperative recovery (2.95 ± 0.29 h), and rapid decrease of the postoperative impairment score to 0 (3.28 ± 0.36 h). Reproducible defect creation and cement filling was documented by intraoperative x-ray and ex vivo conventional/micro-CT. Vertebral cement augmentation and osteoconductivity of the CPC was validated by osteodensitometry, micro-CT, histology/static histomorphometry, fluorescence histomorphometry, and compressive strength measurements.

Conclusion:

This minimally-invasive, ventrolateral, lumbar vertebroplasty model in aged, osteopenic sheep shows short operation times, rapid postoperative recovery, and high experimental reproducibility and may thus represent a good basis for standardized evaluation of future studies on vertebral augmentation with resorbable and osteoconductive CPC.

 

Speaker:
Francesca Gunnella
Jena University Hospital
Additional Authors:
  • Dr. Matthias Bungartz
    Jena University Hospital, Germany
  • Dr. Stefan Maenz
    Friedrich-Schiller-University Jena, Germany
  • Dr. Elke Kunisch
    Jena University Hospital, Germany
  • Victoria Horbert
    Jena University Hospital, Germany
  • Dr. Long Xin
    Jena University Hospital, Germany
  • Francesca Gunnella
    Jena University Hospital, Germany
  • Dr. Joerg Mika
    University Hospital Giessen-Marburg, Campus Giessen
  • Juliane Borowski
    Jena University Hospital, Germany
  • Dr. Sabine Bischoff
    Jena University Hospital, Germany
  • Dr. Harald Schubert
    Jena University Hospital, Germany
  • Dr. Andre Sachse
    Jena University Hospital, Germany
  • Dr. Bernhard Illerhaus
    BAM Bundesanstalt für Materialforschung und –prüfung (BAM), Berlin
  • Prof. Dr. Jens Günster
    BAM Bundesanstalt für Materialforschung und –prüfung (BAM), Berlin
  • Dr. Joerg Bossert
    Friedrich-Schiller-University Jena, Germany
  • Prof. Dr. Klaus Jandt
    Friedrich-Schiller-University Jena, Germany
  • Dr. Olaf Brinkmann
    Jena University Hospital, Germany