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Poster Presentation

In vivo performance of polymeric photodynamic active biomaterials for periodontal regeneration

Sunday (01.01.2040)
00:00 - 08:17
Part of:
Line-Up:
- Poster Presentation The European user access program nanoscience foundries and fine analysis (NFFA) 0 Dr.-Ing. Thomas F. Keller
- Poster Presentation Sarcoma osteogenic-like Saos-2 cells on the silica nanofibres coated with nanodiamond 1 Marie Steinerova
- Poster Presentation Sputtered, micro structured freestanding FeMn foils as biodegradable material 0 Till Jurgeleit
- Poster Presentation Exploring the effects of organic components on the degradation of magnesium in vitro under physiological conditions 1 Ph.D. Ruiqing Hou
- Poster Presentation Influence of laser treatment on the corrosion behavior of Mg-1Zn-1Ca and Mg-3Zn-0.3Ca alloys 1 Ph.D. Nuria Pulido González
- Poster Presentation PLA based CaCO3 composite fibers for textile scaffolds in hard tissue regeneration 1 Dr.-Ing. Claudia Hinüber
- Poster Presentation Functionalization of polymer fibers with heparan sulfate as a representative of the extracellular matrix 1 Inga Wille
- Poster Presentation Development and Characterization of Hybrid Hydrogel Based on Oxidized Alginate and Keratin for Tissue Engineering Applications 0 Supachai Reakasame
- Poster Presentation Nir Laser-responsive Folate-targeted Gold Nanorods As Efficient theranostic tool for Osteosarcoma Treatment 1 Ph.D. Nicol? Mauro
- Poster Presentation Mechanical properties of recent CAD/CAM polymer materials 1 Sebastian Spintzyk
- Poster Presentation Multilayers of Nanoparticles with Alginate, Chondroitin sulfate and Hyaluronic acid for graded implants 1 Steffen Sydow
- Poster Presentation Design of drug eluting ophthalmic lenses through a multi-layer approach 1 Dr. Ana Topete
- Poster Presentation Drug loaded silicon based soft contact lenses: effect of terminal sterilization methods on their performance 1 Andreia Sofia Oliveira
- Poster Presentation Investigating the compressibility of spray dried alumina-zirconia granules for use in orthopaedics - an easy to use and fast method 1 Dr. Ranko Adjiski
- Poster Presentation Biochemical modification of extruded protein nanofibers 1 Karsten Stapelfeldt
- Poster Presentation Microfibers and Nanoparticles with Controlled Dimensions of a Hyaluronic Acid Derivative 1 Ph.D. Calogero Fiorica
- Poster Presentation Modeling the Viscosity of Silicone Rubber During High-Speed Infrared Curing 1 Jan Stieghorst
- Poster Presentation Effect of the pH of bleaching H2O2 solutions in the enamel morphology, hardness and color 1 Dr. Ana Topete
- Poster Presentation New crosslinking diluents for dental materials 1 Prof. Dr. Norbert Moszner
- Poster Presentation Microstructure and Properties of Plasma Sprayed Bioactive Glass Ceramics Coatings 1 Annamária Dobrádi
- Poster Presentation Impact of chloride ions on apatite mineralisation on Bioglass® 45S5 0 Juliane Brandt-Slowik
- Poster Presentation In vivo performance of polymeric photodynamic active biomaterials for periodontal regeneration 1 Dr. Stefan Kranz
- Poster Presentation Adjusted material-cell interaction using engineered spider silk proteins 1 Vanessa Trossmann
- Poster Presentation Cellular interactions with extruded protein nanofibers 1 Naiana Suter
- Poster Presentation Antimicrobial efficacy of strontium and zinc glasses and glass ionomer cements against clinically relevant bacteria 0 Hawshan Mustafa
- Poster Presentation Mechanical properties of water-soluble polyvinyl alcohol parts fabricated by fused deposition modelling 1 Jochen Kuttig
- Poster Presentation Corrosion behavior of dental CoCr alloys made by different digital workflow processes compared to cast CoCr alloys 0 Christine Schille
- Poster Presentation Mechanical properties of biocompatible polymer-based resin for dental applications fabricated by stereolithography 1 Phan Hai-Binh Bui

Session P.2: Poster Session 2
Belongs to:
Topic P: Postersession


Introduction

For periodontal regeneration biomaterials can be applied in order to restore the function and stability of the periodontium. The aim of the present animal study was to evaluate the integration as well as the osteoconductive and osteoinductive properties of new designed polymeric photodynamic active biomaterials.


Materials and Methods

Two new designed polymeric biomaterials based on polyurethanmethacrylate (BioM1) and polyesterurethantrimethacrylate (BioM2), mixed with β-tricalciumphosphate and the photosensitizer mTHPC were transplanted into the Femur and Tibia of sheep. Therefore, bone lesions were drilled and filled with the respective biomaterial (test sites). The control sites were sealed with bone wax, only. Regularly, the sheep received intravenous injections with fluorochrome labels. After 9 month the animals were scarified and the transplants removed. The fixed samples were radiographically analyzed by µCT and observed by laser scanning microscopy.


Results

The highest rate of bone formation was observed among sites treated with BioM2. For both materials identical numbers in trabecular bone formation was realized. Overall, BioM1 led to an increased formation of femoral trabecular bone, whereas BioM2 induced a more compact tibial bone growth with mainly fused trabeculae.


Conclusions

As shown by the results, both materials present excellent osteoconductive and osteoinductive properties and are potential candidates for further periodontal regeneration studies.

 

Speaker:
Dr. Stefan Kranz
Jena University Hospital
Additional Authors:
  • Micheal Durkalets
    University Hospital Jena
  • Andrea Voelpel
    University Hospital Jena
  • Dr. Andre Guellmar
    University Hospital Jena
  • Dr. Albrecht Berg
    Innovent e.V.
  • Prof. Dr. Volker Albrecht
    biolitec GmbH
  • Prof. Dr. Bernd Sigusch
    University Hospital Jena