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Poster Presentation

Nir Laser-responsive Folate-targeted Gold Nanorods As Efficient theranostic tool for Osteosarcoma Treatment

Sunday (01.01.2040)
00:00 - 08:31
Part of:
Line-Up:
- Poster Presentation The European user access program nanoscience foundries and fine analysis (NFFA) 0 Dr.-Ing. Thomas F. Keller
- Poster Presentation Sarcoma osteogenic-like Saos-2 cells on the silica nanofibres coated with nanodiamond 1 Marie Steinerova
- Poster Presentation Sputtered, micro structured freestanding FeMn foils as biodegradable material 0 Till Jurgeleit
- Poster Presentation Exploring the effects of organic components on the degradation of magnesium in vitro under physiological conditions 1 Ph.D. Ruiqing Hou
- Poster Presentation Influence of laser treatment on the corrosion behavior of Mg-1Zn-1Ca and Mg-3Zn-0.3Ca alloys 1 Ph.D. Nuria Pulido González
- Poster Presentation PLA based CaCO3 composite fibers for textile scaffolds in hard tissue regeneration 1 Dr.-Ing. Claudia Hinüber
- Poster Presentation Functionalization of polymer fibers with heparan sulfate as a representative of the extracellular matrix 1 Inga Wille
- Poster Presentation Development and Characterization of Hybrid Hydrogel Based on Oxidized Alginate and Keratin for Tissue Engineering Applications 0 Supachai Reakasame
- Poster Presentation Nir Laser-responsive Folate-targeted Gold Nanorods As Efficient theranostic tool for Osteosarcoma Treatment 1 Ph.D. Nicol? Mauro
- Poster Presentation Mechanical properties of recent CAD/CAM polymer materials 1 Sebastian Spintzyk
- Poster Presentation Multilayers of Nanoparticles with Alginate, Chondroitin sulfate and Hyaluronic acid for graded implants 1 Steffen Sydow
- Poster Presentation Design of drug eluting ophthalmic lenses through a multi-layer approach 1 Dr. Ana Topete
- Poster Presentation Drug loaded silicon based soft contact lenses: effect of terminal sterilization methods on their performance 1 Andreia Sofia Oliveira
- Poster Presentation Investigating the compressibility of spray dried alumina-zirconia granules for use in orthopaedics - an easy to use and fast method 1 Dr. Ranko Adjiski
- Poster Presentation Biochemical modification of extruded protein nanofibers 1 Karsten Stapelfeldt
- Poster Presentation Microfibers and Nanoparticles with Controlled Dimensions of a Hyaluronic Acid Derivative 1 Ph.D. Calogero Fiorica
- Poster Presentation Modeling the Viscosity of Silicone Rubber During High-Speed Infrared Curing 1 Jan Stieghorst
- Poster Presentation Effect of the pH of bleaching H2O2 solutions in the enamel morphology, hardness and color 1 Dr. Ana Topete
- Poster Presentation New crosslinking diluents for dental materials 1 Prof. Dr. Norbert Moszner
- Poster Presentation Microstructure and Properties of Plasma Sprayed Bioactive Glass Ceramics Coatings 1 Annamária Dobrádi
- Poster Presentation Impact of chloride ions on apatite mineralisation on Bioglass® 45S5 0 Juliane Brandt-Slowik
- Poster Presentation In vivo performance of polymeric photodynamic active biomaterials for periodontal regeneration 1 Dr. Stefan Kranz
- Poster Presentation Adjusted material-cell interaction using engineered spider silk proteins 1 Vanessa Trossmann
- Poster Presentation Cellular interactions with extruded protein nanofibers 1 Naiana Suter
- Poster Presentation Antimicrobial efficacy of strontium and zinc glasses and glass ionomer cements against clinically relevant bacteria 0 Hawshan Mustafa
- Poster Presentation Mechanical properties of water-soluble polyvinyl alcohol parts fabricated by fused deposition modelling 1 Jochen Kuttig
- Poster Presentation Corrosion behavior of dental CoCr alloys made by different digital workflow processes compared to cast CoCr alloys 0 Christine Schille
- Poster Presentation Mechanical properties of biocompatible polymer-based resin for dental applications fabricated by stereolithography 1 Phan Hai-Binh Bui

Session P.2: Poster Session 2
Belongs to:
Topic P: Postersession


Anna Li Volsi,1 Mariano Licciardi,1,3 Cinzia Scialabba,1 Nicolò Mauro,1 Paola Varvarà,1 Valeria Vetri,2,3 Gennara Cavallaro,1 Gaetano Giammona1,3

1Department of Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi, 32, 90123 Palermo, Italy.

2Department of Physics and Chemistry, University of Palermo, Palermo, Italy

3Mediterranean Center for Human Health Advanced Biotechnologies (CHAB), Italy

Folate-targeted gold nanorods (GNRs) are here proposed as selective theranostic agents for osteosarcoma treatment. Taking advantage of the attractive physiochemical and optical properties of GNRs they can be proposed as effective and selective platform to obtain a targeted intracellular drug release, photothermal therapy and cancer imaging, which may improve therapeutic outcomes of osteosarcoma. An amphiphilic polysaccharide graft-copolymer, named INU-LA-PEG-FA, and a folic acid functionalized α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA-FA), have been synthesized to act as coating agents for GNRs. The obtained polymer-coated GNRs were characterized in terms of size, shape, zeta potential, chemical composition, aqueous stability. They protected the anticancer drug nutlin-3 in human plasma and were able to deliver it efficiently in different physiological media. The proposed systems selectively exert their toxic effect towards U2OS cancer cells expressing high levels of FRs compared with normal human bronchial epithelial cells (16HBE) and human dermal fibroblasts (HDFa). Moreover, we report the ability of the nanosystems of efficiently controlling drug release upon NIR laser irradiation and of acting as an excellent hyperthermia agent as well as Two Photon Luminescence imaging contrast agents. The proposed folate-targeted GNRs have also been tested in terms of chemoterapeutic and thermoablation efficacy on tridimensional (3-D) osteosarcoma models which better mimic cancer microenvironments and therefore offer the promise of improving clinical efficacy. Overall, the proposed folate targeted GNRs displayed outstanding anticancer activity on bidimensional and on 3-D tumor models, making them appealing multimodal agents for image-guided therapies based on localized hyperthermia and chemoterapy of solid tumors.

 

Speaker:
Ph.D. Nicol? Mauro
University of Palermo
Additional Authors:
  • Anna Li Volsi
    University of Palermo
  • Prof. Dr. Mariano Licciardi
    University of Palermo
  • Dr. Cinzia Scialabba
    University of Palermo
  • Paola Varvarà
    University of Palermo
  • Prof. Dr. Valeria Vetri
    University of Palermo
  • Prof. Gennara Cavallaro
    University of Palermo
  • Prof. Gaetano Giammona
    University of Palermo