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Oral Poster

Attachment of Nanoparticle Drug-Release Systems on Shish-Kebab structured Poly(?-Caprolactone) Nanofibers

Tuesday (09.05.2017)
19:00 - 19:03
Part of:
Line-Up:
18:00 Oral Poster Fibrinogen Adsorption and Network Formation on Melt Drawn Isotactic Polybutene-1 Thin Films 1 Xiaoyuan Zhang
18:03 Oral Poster Characterization of biomaterials using AFM based fast nanoscale imaging and quantitative nanomechanical techniques 1 Dr. Tanja Neumann
18:06 Oral Poster Hydrothermal conversion of porous Ca carbonate biominerals into bioactive Ca phosphate materials: towards antibiotic and antiosteoporotic bone graft substitutes 1 Dr. Ingo Sethmann
18:09 Oral Poster Study on the retarding effect of phytic acid on the hydration of a brushite cement 1 Dr. Katrin Hurle
18:12 Oral Poster Synthesis of hollow mesoporous bioactive glass nanoparticles with uniform size and shape 1 Kai Zheng
18:15 Oral Poster Systematic post-operative clinical assessment of lumbar ventrolateral vertebroplasty in the large animal model sheep using a minimally-invasive approach 1 Francesca Gunnella
18:18 Oral Poster Dual setting system – characterization of PEG-based-hydrogel/brushite composites for biomedical application 1 Michaela Rödel
18:21 Oral Poster The effect of HAc etching on the degradation behaviour of Mg-5Gd 1 Dr. Frank Feyerabend
18:24 Oral Poster Degradation behavior of as cast and powder metallurgy processed Mg-Ca alloys 0 Dipl.-Ing. Eshwara Phani Shubhakar Nidadavolu
18:27 Oral Poster Bio-inspired high-performance green biopolymer fibers 1 Dr. Hendrik Bargel
18:30 Oral Poster Diatom Biosilica for Catalytic and Adsorptive Applications 1 Cathleen Fischer
18:33 Oral Poster Gallotannin polyphenol enhancement of biomimetic enzymatic hydrogel mineralization 1 Dr. Timothy E.L. Douglas
18:36 Oral Poster Starch in textile application: Modification, processing and product development 1 Pavan Kumar Manvi
18:39 Oral Poster Recombinant Spider Silk Proteins Used as Biomedical Coating Material 1 Christian Borkner
18:42 Oral Poster Effects of cross-linking modifications on Collagen: a preliminary biological evaluation 1 Dr. Mattia Vacchini
18:45 Oral Poster Endothelialization of polymethylpentene fibers as a step towards patient-specific medical devices 1 M.Sc. Annika Wenz
18:48 Oral Poster Hybrid poly-lactide/gelatin electrospun scaffolds with controlled hydrophilicity and wettability. 1 Germano Piccirillo
18:51 Oral Poster Funktion and structure - Combined optical functionality and specific bio-interaction for multifunctional biomedical materials 1 Dr. Tina Sabel
18:57 Oral Poster Bacterial adhesion to PEEK compared to exemplary dental ceramic, metallic and composite materials 1 Dr. Lutz Scheideler
19:00 Oral Poster Attachment of Nanoparticle Drug-Release Systems on Shish-Kebab structured Poly(?-Caprolactone) Nanofibers 1 Dominik de Cassan
19:06 Oral Poster Improved Nanofleeces for Cell Culture Applications 1 Tobias Kürbitz

Session P.1: Oral Poster Session 1
Belongs to:
Topic P: Postersession


The use of biocompatible and biodegradable materials as implants is a promising approach to temporarily replace endogenous functions and replace tissue during a healing process. Electrospun fiber mats can be used in the field of tissue engineering (TE) and to engineer tendon/ligament-to-bone interfaces, showing high surface to volume ratio and a good roughness, which is promising for initial cell attachment and growth. Using Polycaprolactone (PCL) as a basic material for implants is favorable because of its good mechanical properties and its slow degradation. However, due to its hydrophobic characteristics PCL is an unfavorable material for cell attachment and growth. Multiple approaches have been made to improve the cellular behavior such as plasma treatment or chemical modification. Another approach uses a “shish-kebab” coating of the electrospun fibers. Chitosan (CS)-PCL graft copolymers (CS-g-PCL) can spontaneously crystallize as kebabs on PCL nanofibers which act as shishes.

The graft-polymerization to synthesize CS-g-PCL copolymer is easy to perform and can be nicely controlled. Specific graft lengths and ratios for the PCL side-arms are accessible. The “shish-kebab” coating of CS-g-PCL onto electrospun PCL fibers is a fast and scalable approach to create fibermats more attractive for human cells. Additionally using CS-g-PCL for PCL surface modification creates surface charges on the fibers due to the presence of amino groups. This allows the attachment of nanoparticle drug-release systems using electrostatic interactions in an easy and scalable process.

The organic nanoparticles (chitosan-tripolyphosphate-, alginate-poly-L-lysin) do not form stable and clearly distinguishable particles when adsorbed onto the fiber surface, however, they seem to form a film as it already has been described previously. This makes it difficult to proof the coating via REM. However, using fluorescently labeled nanoparticles and CLSM hollow structures can be established indicting, that only the surface of the modified PCL nanofibers is coated with the labeled drug-release systems. The inorganic nanoparticles (silica-system) can be clearly identified using REM and CLSM. They are well distributed among the whole sample surface and show minor aggregation.

 

Speaker:
Dominik de Cassan
TU Braunschweig
Additional Authors:
  • Prof. Henning Menzel
    TU Braunschweig
  • Prof. Peter Behrens
    Leibniz Universität Hannover
  • Nadeschda Schmidt
    Leibniz Universität Hannover
  • Steffen Sydow
    TU Braunschweig