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Poster Presentation

Functionalization of polymer fibers with heparan sulfate as a representative of the extracellular matrix

Part of:
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- Poster Presentation PLA based CaCO3 composite fibers for textile scaffolds in hard tissue regeneration 1 Dr.-Ing. Claudia Hinüber
- Poster Presentation Functionalization of polymer fibers with heparan sulfate as a representative of the extracellular matrix 1 Inga Wille
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- Poster Presentation Mechanical properties of recent CAD/CAM polymer materials 1 Sebastian Spintzyk
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- Poster Presentation Investigating the compressibility of spray dried alumina-zirconia granules for use in orthopaedics - an easy to use and fast method 1 Dr. Ranko Adjiski
- Poster Presentation Biochemical modification of extruded protein nanofibers 1 Karsten Stapelfeldt
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- Poster Presentation Modeling the Viscosity of Silicone Rubber During High-Speed Infrared Curing 1 Jan Stieghorst
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- Poster Presentation Impact of chloride ions on apatite mineralisation on Bioglass® 45S5 0 Juliane Brandt-Slowik
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- Poster Presentation Antimicrobial efficacy of strontium and zinc glasses and glass ionomer cements against clinically relevant bacteria 0 Hawshan Mustafa
- Poster Presentation Mechanical properties of water-soluble polyvinyl alcohol parts fabricated by fused deposition modelling 1 Jochen Kuttig
- Poster Presentation Corrosion behavior of dental CoCr alloys made by different digital workflow processes compared to cast CoCr alloys 0 Christine Schille
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Session P.2: Poster Session 2
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Topic P: Postersession

The application of polymer fibers consisting of poly-ε-caprolactone (PCL) and polyglycolide (PGA) has already been widely studied in the field of biomedical sciences. Both polymers have been used for example as basic material for drug delivery systems or 3D-scaffolds in tissue engineering. They allow an efficient modification of their physical, chemical and mechanical properties by copolymerization or blending with many other polymers as well as by surface functionalization. Moreover they have shown a good biocompatibility and are biodegradable.[1] The aim of this work is to modify the surface of fibers made from PCL/PGA copolymers in order to test their applicability as components in scaffolds for tissue regeneration. For this purpose, the biodegradable fibers were coated with heparan sulfate as a representative of extracellular matrix components; heparan sulfate is also an anticoagulant and could enhance wound healing after implantation.[2] It is well-known in clinical applications and is, for example, used in the eyedrops Cacicol® to regenerate and heal the cornea.

In this work the polymer fibers are functionalized with aminogroups via aminolysis using ethylenediamine.[3] Afterwards heparan sulfate is linked covalently to the functionalized fibers using coupling and stabilizing agents.[4] Toluidine blue was used in a colorimetric assay to validate the presence of heparan sulfate on the fibers.[5] Furthermore, cell culture investigations with fibroblasts showed a good cytocompatibility.

This work was supported by the Cluster of Excellence Hearing4all.

[1] YOO, H. S., KIM, T. G., PARK, T. G.; Adv. Drug Deliv. Rev.; 2009; 61; 12; 1033–1042.

[2] RABENSTEIN, D. L.; Nat. Prod. Rep.; 2002; 19; 1 4; 312–331.

[3] ZHU, Y., LEONG, M. F., ONG, W. F., CHAN-PARK, M. B., CHIAN, K. S.; Biomater.; 2007; 28; 861–868.

[4] PIEPER, J. S., VAN WACHEM, P. B., VAN LUYN, M. J. a, BROUWER, L. a., HAFMANS, T., VEERKAMP, J. H., VAN KUPPEVELT, T. H.; Biomater.; 2000; 21; 1689–1699.

[5] MACINTOSH, F. C.; Biochem. J.; 1941; 35; 776–82.

Inga Wille
Leibniz University Hannover
Additional Authors:
  • Prof. Dr. Peter Behrens
    Leibniz Universität Hannover
  • Dr. Athanasia Warnecke
    Medizinische Hochschule Hannover