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Poster Presentation

PLA based CaCO3 composite fibers for textile scaffolds in hard tissue regeneration

Sunday (01.01.2040)
00:00 - 08:09
Part of:
Line-Up:
- Poster Presentation The European user access program nanoscience foundries and fine analysis (NFFA) 0 Dr.-Ing. Thomas F. Keller
- Poster Presentation Sarcoma osteogenic-like Saos-2 cells on the silica nanofibres coated with nanodiamond 1 Marie Steinerova
- Poster Presentation Sputtered, micro structured freestanding FeMn foils as biodegradable material 0 Till Jurgeleit
- Poster Presentation Exploring the effects of organic components on the degradation of magnesium in vitro under physiological conditions 1 Ph.D. Ruiqing Hou
- Poster Presentation Influence of laser treatment on the corrosion behavior of Mg-1Zn-1Ca and Mg-3Zn-0.3Ca alloys 1 Ph.D. Nuria Pulido González
- Poster Presentation PLA based CaCO3 composite fibers for textile scaffolds in hard tissue regeneration 1 Dr.-Ing. Claudia Hinüber
- Poster Presentation Functionalization of polymer fibers with heparan sulfate as a representative of the extracellular matrix 1 Inga Wille
- Poster Presentation Development and Characterization of Hybrid Hydrogel Based on Oxidized Alginate and Keratin for Tissue Engineering Applications 0 Supachai Reakasame
- Poster Presentation Nir Laser-responsive Folate-targeted Gold Nanorods As Efficient theranostic tool for Osteosarcoma Treatment 1 Ph.D. Nicol? Mauro
- Poster Presentation Mechanical properties of recent CAD/CAM polymer materials 1 Sebastian Spintzyk
- Poster Presentation Multilayers of Nanoparticles with Alginate, Chondroitin sulfate and Hyaluronic acid for graded implants 1 Steffen Sydow
- Poster Presentation Design of drug eluting ophthalmic lenses through a multi-layer approach 1 Dr. Ana Topete
- Poster Presentation Drug loaded silicon based soft contact lenses: effect of terminal sterilization methods on their performance 1 Andreia Sofia Oliveira
- Poster Presentation Investigating the compressibility of spray dried alumina-zirconia granules for use in orthopaedics - an easy to use and fast method 1 Dr. Ranko Adjiski
- Poster Presentation Biochemical modification of extruded protein nanofibers 1 Karsten Stapelfeldt
- Poster Presentation Microfibers and Nanoparticles with Controlled Dimensions of a Hyaluronic Acid Derivative 1 Ph.D. Calogero Fiorica
- Poster Presentation Modeling the Viscosity of Silicone Rubber During High-Speed Infrared Curing 1 Jan Stieghorst
- Poster Presentation Effect of the pH of bleaching H2O2 solutions in the enamel morphology, hardness and color 1 Dr. Ana Topete
- Poster Presentation New crosslinking diluents for dental materials 1 Prof. Dr. Norbert Moszner
- Poster Presentation Microstructure and Properties of Plasma Sprayed Bioactive Glass Ceramics Coatings 1 Annamária Dobrádi
- Poster Presentation Impact of chloride ions on apatite mineralisation on Bioglass® 45S5 0 Juliane Brandt-Slowik
- Poster Presentation In vivo performance of polymeric photodynamic active biomaterials for periodontal regeneration 1 Dr. Stefan Kranz
- Poster Presentation Adjusted material-cell interaction using engineered spider silk proteins 1 Vanessa Trossmann
- Poster Presentation Cellular interactions with extruded protein nanofibers 1 Naiana Suter
- Poster Presentation Antimicrobial efficacy of strontium and zinc glasses and glass ionomer cements against clinically relevant bacteria 0 Hawshan Mustafa
- Poster Presentation Mechanical properties of water-soluble polyvinyl alcohol parts fabricated by fused deposition modelling 1 Jochen Kuttig
- Poster Presentation Corrosion behavior of dental CoCr alloys made by different digital workflow processes compared to cast CoCr alloys 0 Christine Schille
- Poster Presentation Mechanical properties of biocompatible polymer-based resin for dental applications fabricated by stereolithography 1 Phan Hai-Binh Bui

Session P.2: Poster Session 2
Belongs to:
Topic P: Postersession


Facing the extremely complex biological system of human organism, the requirements for scaffold materials in regenerative medicine are enormous and tremendously challenging. Reconstruction of bone is one of the most intensively investigated areas, therefore the demands on scaffolds are well defined: biocompatibility, creation of a 3D-network with desired pore size and interconnectivity for directed cell growth and support of vascularization of the ingrown tissue, certain mechanical, physical and chemical properties and appropriate degradation characteristics with non-toxic residues.

Especially the creation of polymer-based composite materials, mimicing the composite nature of real bone, with inorganic fillers such as hydroxyapatite or calcium carbonate represents an alternative choice to overcome the mechanical limitations and introduce mineral components promoting bone regeneration. Particularly nano-sized fillers have been stated to exhibit special properties, e.g. increased bioactivity, due to the huge specific surface area compared to traditional micro-sized ceramic materials.

Polylactide (PLA) is a resorbable medically approved osteosynthesis material, that is limited in its application due its inherent brittleness. However, fabricated into fibers the remarkable potential of PLA is evident: silk-like fibers with 20-200% elongation of break can be fabricated. Thus, PLA fibers have emerged in to the textile industry applications. Further textile processing, e.g. embroidery technology, allows for various scaffolds designs with adjustable scaffold geometry, porosity and mechanical properties.

Therefore, the aim of our ongoing study is the fabrication and investigation of PLA based composite fibers with incorporated nano-sized CaCO3. Our first results concerning the textile-mechanical properties, degradation rate, calcium release and hydroxycarbonate apatite forming ability in simulated body fluid are presented.

 

Speaker:
Dr.-Ing. Claudia Hinüber
Leibniz Institute of Polymer Research Dresden (IPF)
Additional Authors:
  • Dr. Harald Brünig
    Leibniz-Institut für Polymerforschung Dresden e.V.
  • Dr. Uwe Gohs
    Leibniz-Institut für Polymerforschung Dresden e.V.
  • Julia Tondera
    Technische Universität Dresden
  • Prof. Dr. Gert Heinrich
    Leibniz-Institut für Polymerforschung Dresden e.V.