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Oral Poster

Hydrothermal conversion of porous Ca carbonate biominerals into bioactive Ca phosphate materials: towards antibiotic and antiosteoporotic bone graft substitutes

Tuesday (09.05.2017)
18:06 - 18:09
Part of:
18:00 Oral Poster Fibrinogen Adsorption and Network Formation on Melt Drawn Isotactic Polybutene-1 Thin Films 1 Xiaoyuan Zhang
18:03 Oral Poster Characterization of biomaterials using AFM based fast nanoscale imaging and quantitative nanomechanical techniques 1 Dr. Tanja Neumann
18:06 Oral Poster Hydrothermal conversion of porous Ca carbonate biominerals into bioactive Ca phosphate materials: towards antibiotic and antiosteoporotic bone graft substitutes 1 Dr. Ingo Sethmann
18:09 Oral Poster Study on the retarding effect of phytic acid on the hydration of a brushite cement 1 Dr. Katrin Hurle
18:12 Oral Poster Synthesis of hollow mesoporous bioactive glass nanoparticles with uniform size and shape 1 Kai Zheng
18:15 Oral Poster Systematic post-operative clinical assessment of lumbar ventrolateral vertebroplasty in the large animal model sheep using a minimally-invasive approach 1 Francesca Gunnella
18:18 Oral Poster Dual setting system – characterization of PEG-based-hydrogel/brushite composites for biomedical application 1 Michaela Rödel
18:21 Oral Poster The effect of HAc etching on the degradation behaviour of Mg-5Gd 1 Dr. Frank Feyerabend
18:24 Oral Poster Degradation behavior of as cast and powder metallurgy processed Mg-Ca alloys 0 Dipl.-Ing. Eshwara Phani Shubhakar Nidadavolu
18:27 Oral Poster Bio-inspired high-performance green biopolymer fibers 1 Dr. Hendrik Bargel
18:30 Oral Poster Diatom Biosilica for Catalytic and Adsorptive Applications 1 Cathleen Fischer
18:33 Oral Poster Gallotannin polyphenol enhancement of biomimetic enzymatic hydrogel mineralization 1 Dr. Timothy E.L. Douglas
18:36 Oral Poster Starch in textile application: Modification, processing and product development 1 Pavan Kumar Manvi
18:39 Oral Poster Recombinant Spider Silk Proteins Used as Biomedical Coating Material 1 Christian Borkner
18:42 Oral Poster Effects of cross-linking modifications on Collagen: a preliminary biological evaluation 1 Dr. Mattia Vacchini
18:45 Oral Poster Endothelialization of polymethylpentene fibers as a step towards patient-specific medical devices 1 M.Sc. Annika Wenz
18:48 Oral Poster Hybrid poly-lactide/gelatin electrospun scaffolds with controlled hydrophilicity and wettability. 1 Germano Piccirillo
18:51 Oral Poster Funktion and structure - Combined optical functionality and specific bio-interaction for multifunctional biomedical materials 1 Dr. Tina Sabel
18:57 Oral Poster Bacterial adhesion to PEEK compared to exemplary dental ceramic, metallic and composite materials 1 Dr. Lutz Scheideler
19:00 Oral Poster Attachment of Nanoparticle Drug-Release Systems on Shish-Kebab structured Poly(?-Caprolactone) Nanofibers 1 Dominik de Cassan
19:06 Oral Poster Improved Nanofleeces for Cell Culture Applications 1 Tobias Kürbitz

Session P.1: Oral Poster Session 1
Belongs to:
Topic P: Postersession

Millions of bone graft procedures are performed annually for repairing bone defects. Synthetic calcium phosphate-based (CaP) materials are commonly used as bone graft substitutes. Their chemical similarity to bone guarantees biocompatibility while macroporosity of CaP materials enables ingrowth of natural bone tissue and firm integration into the bone. Since the mechanical performance of the synthetic materials is generally inferior to natural bone, gradual resorption of CaP implants and simultaneous replacement by natural bone is desirable. Hydroxyapatite (HA), as the thermodynamically most stable CaP phase in the human body, is almost non-resorbable. Therefore, many CaP implants are designed as biphasic calcium phosphate (BCP) composites of HA and the more soluble tricalcium phosphate (similar to the mineral whitlockite). In the presence of Mg ions, the formation of whitlockite is favoured over hydroxyapatite. During degradation of BCP implants, whitlockite-incorporated Mg ions are released and stimulate the formation of natural bone.[1] Furthermore, Sr ions are known to stimulate bone formation and retard bone resorption at the same time.[2] Hence, resorbable Mg- and Sr-containing implants may counteract bone loss and fracture related to osteoporosis.[3] Additionally, the antibacterial effect of Ag ions could be employed to avoid wound infection during surgical graft procedures.

Aiming at the development of novel antiosteoporotic and antimicrobial bone implant materials, macroporous biominerals, such as skeletal materials of coral (aragonite, CaCO3) and sea urchins (Mg-calcite, Ca0.9Mg0.1CaCO3), were pseudomorphically replaced by CaP while the natural porosity was preserved. During hydrothermal mineral replacement, Sr ions, in phosphate solutions temporarily stabilized by EDTA, were incorporated into the HA phase of the resulting material. This approach was unsuccessful for Mg incorporation. Superficial replacement of CaP materials in AgNO3 solution produced Ag phosphate coatings, endowing them with antibiotic properties.


Dr. Ingo Sethmann
Technische Universität Darmstadt
Additional Authors:
  • Cornelia Luft
    Technische Universität Darmstadt
  • Sabrina Völkel
    Technische Universität Darmstadt
  • Prof. Dr. Felicitas Pfeifer
    Technische Universität Darmstadt
  • Prof. Dr. Hans-Joachim Kleebe
    Technische Universität Darmstadt