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Oral Poster

Fibrinogen Adsorption and Network Formation on Melt Drawn Isotactic Polybutene-1 Thin Films

Tuesday (09.05.2017)
18:00 - 18:03
Part of:
18:00 Oral Poster Fibrinogen Adsorption and Network Formation on Melt Drawn Isotactic Polybutene-1 Thin Films 1 Xiaoyuan Zhang
18:03 Oral Poster Characterization of biomaterials using AFM based fast nanoscale imaging and quantitative nanomechanical techniques 1 Dr. Tanja Neumann
18:06 Oral Poster Hydrothermal conversion of porous Ca carbonate biominerals into bioactive Ca phosphate materials: towards antibiotic and antiosteoporotic bone graft substitutes 1 Dr. Ingo Sethmann
18:09 Oral Poster Study on the retarding effect of phytic acid on the hydration of a brushite cement 1 Dr. Katrin Hurle
18:12 Oral Poster Synthesis of hollow mesoporous bioactive glass nanoparticles with uniform size and shape 1 Kai Zheng
18:15 Oral Poster Systematic post-operative clinical assessment of lumbar ventrolateral vertebroplasty in the large animal model sheep using a minimally-invasive approach 1 Francesca Gunnella
18:18 Oral Poster Dual setting system – characterization of PEG-based-hydrogel/brushite composites for biomedical application 1 Michaela Rödel
18:21 Oral Poster The effect of HAc etching on the degradation behaviour of Mg-5Gd 1 Dr. Frank Feyerabend
18:24 Oral Poster Degradation behavior of as cast and powder metallurgy processed Mg-Ca alloys 0 Dipl.-Ing. Eshwara Phani Shubhakar Nidadavolu
18:27 Oral Poster Bio-inspired high-performance green biopolymer fibers 1 Dr. Hendrik Bargel
18:30 Oral Poster Diatom Biosilica for Catalytic and Adsorptive Applications 1 Cathleen Fischer
18:33 Oral Poster Gallotannin polyphenol enhancement of biomimetic enzymatic hydrogel mineralization 1 Dr. Timothy E.L. Douglas
18:36 Oral Poster Starch in textile application: Modification, processing and product development 1 Pavan Kumar Manvi
18:39 Oral Poster Recombinant Spider Silk Proteins Used as Biomedical Coating Material 1 Christian Borkner
18:42 Oral Poster Effects of cross-linking modifications on Collagen: a preliminary biological evaluation 1 Dr. Mattia Vacchini
18:45 Oral Poster Endothelialization of polymethylpentene fibers as a step towards patient-specific medical devices 1 M.Sc. Annika Wenz
18:48 Oral Poster Hybrid poly-lactide/gelatin electrospun scaffolds with controlled hydrophilicity and wettability. 1 Germano Piccirillo
18:51 Oral Poster Funktion and structure - Combined optical functionality and specific bio-interaction for multifunctional biomedical materials 1 Dr. Tina Sabel
18:57 Oral Poster Bacterial adhesion to PEEK compared to exemplary dental ceramic, metallic and composite materials 1 Dr. Lutz Scheideler
19:00 Oral Poster Attachment of Nanoparticle Drug-Release Systems on Shish-Kebab structured Poly(?-Caprolactone) Nanofibers 1 Dominik de Cassan
19:06 Oral Poster Improved Nanofleeces for Cell Culture Applications 1 Tobias Kürbitz

Session P.1: Oral Poster Session 1
Belongs to:
Topic P: Postersession

Abstract – Human plasma fibrinogen (HPF) network formation is the key factor to initiate blood clotting or coagulation, which can be life-saving but also a severe complication when induced by artificial implant surfaces. Therefore, to understand and control HPF adsorption and network formation is of high importance. To create well-defined, repeatable and technically relevant polymer crystal surfaces, yet with distinct topographies, we rely a well-established morphology of semi-crystalline isotactic poly(butane-1) (iPB-1): shish-kebab crystals and needle-like crystals, by spin-coating and melt-drawing techniques, respectively. The adsorption behavior of HPF in dependence of two surface topographies were investigated by atomic force microscopy (AFM) and quartz crystal microbalance with dissipation (QCM-D). This study shows that the polymer crystal surface topography has a distinct effect on the HPF adsorption and its network formation. Increased number of HPF ring-like networks formed on needle-like crystals (NCs) as compared to the shish-kebab crystals (SKs). The control over the network formation of protein layers on material surfaces is essential for controlling the cell attachment. This understanding may provide a framework for extending the patterning approach to other proteins and material systems.

Keywords – Human plasma fibrinogen, Nanostructure, Polymer crystals, Isotactic Polybutene-1, Melt-drawing

Xiaoyuan Zhang
Friedrich Schiller University Jena
Additional Authors:
  • Dr. Matthias Arras
    Oak Ridge National Laboratory
  • Dr. Claudia Lüdecke-Beyer
    Friedrich Schiller University Jena
  • Christian Helbing
    Friedrich Schiller University Jena
  • Prof. Dr. Klaus Jandt
    Friedrich Schiller University Jena