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Poster Presentation

Development and Characterization of Hybrid Hydrogel Based on Oxidized Alginate and Keratin for Tissue Engineering Applications

Sunday (01.01.2040)
00:00 - 08:14
Part of:
Line-Up:
- Poster Presentation The European user access program nanoscience foundries and fine analysis (NFFA) 0 Dr.-Ing. Thomas F. Keller
- Poster Presentation Sarcoma osteogenic-like Saos-2 cells on the silica nanofibres coated with nanodiamond 1 Marie Steinerova
- Poster Presentation Sputtered, micro structured freestanding FeMn foils as biodegradable material 0 Till Jurgeleit
- Poster Presentation Exploring the effects of organic components on the degradation of magnesium in vitro under physiological conditions 1 Ph.D. Ruiqing Hou
- Poster Presentation Influence of laser treatment on the corrosion behavior of Mg-1Zn-1Ca and Mg-3Zn-0.3Ca alloys 1 Ph.D. Nuria Pulido González
- Poster Presentation PLA based CaCO3 composite fibers for textile scaffolds in hard tissue regeneration 1 Dr.-Ing. Claudia Hinüber
- Poster Presentation Functionalization of polymer fibers with heparan sulfate as a representative of the extracellular matrix 1 Inga Wille
- Poster Presentation Development and Characterization of Hybrid Hydrogel Based on Oxidized Alginate and Keratin for Tissue Engineering Applications 0 Supachai Reakasame
- Poster Presentation Nir Laser-responsive Folate-targeted Gold Nanorods As Efficient theranostic tool for Osteosarcoma Treatment 1 Ph.D. Nicol? Mauro
- Poster Presentation Mechanical properties of recent CAD/CAM polymer materials 1 Sebastian Spintzyk
- Poster Presentation Multilayers of Nanoparticles with Alginate, Chondroitin sulfate and Hyaluronic acid for graded implants 1 Steffen Sydow
- Poster Presentation Design of drug eluting ophthalmic lenses through a multi-layer approach 1 Dr. Ana Topete
- Poster Presentation Drug loaded silicon based soft contact lenses: effect of terminal sterilization methods on their performance 1 Andreia Sofia Oliveira
- Poster Presentation Investigating the compressibility of spray dried alumina-zirconia granules for use in orthopaedics - an easy to use and fast method 1 Dr. Ranko Adjiski
- Poster Presentation Biochemical modification of extruded protein nanofibers 1 Karsten Stapelfeldt
- Poster Presentation Microfibers and Nanoparticles with Controlled Dimensions of a Hyaluronic Acid Derivative 1 Ph.D. Calogero Fiorica
- Poster Presentation Modeling the Viscosity of Silicone Rubber During High-Speed Infrared Curing 1 Jan Stieghorst
- Poster Presentation Effect of the pH of bleaching H2O2 solutions in the enamel morphology, hardness and color 1 Dr. Ana Topete
- Poster Presentation New crosslinking diluents for dental materials 1 Prof. Dr. Norbert Moszner
- Poster Presentation Microstructure and Properties of Plasma Sprayed Bioactive Glass Ceramics Coatings 1 Annamária Dobrádi
- Poster Presentation Impact of chloride ions on apatite mineralisation on Bioglass® 45S5 0 Juliane Brandt-Slowik
- Poster Presentation In vivo performance of polymeric photodynamic active biomaterials for periodontal regeneration 1 Dr. Stefan Kranz
- Poster Presentation Adjusted material-cell interaction using engineered spider silk proteins 1 Vanessa Trossmann
- Poster Presentation Cellular interactions with extruded protein nanofibers 1 Naiana Suter
- Poster Presentation Antimicrobial efficacy of strontium and zinc glasses and glass ionomer cements against clinically relevant bacteria 0 Hawshan Mustafa
- Poster Presentation Mechanical properties of water-soluble polyvinyl alcohol parts fabricated by fused deposition modelling 1 Jochen Kuttig
- Poster Presentation Corrosion behavior of dental CoCr alloys made by different digital workflow processes compared to cast CoCr alloys 0 Christine Schille
- Poster Presentation Mechanical properties of biocompatible polymer-based resin for dental applications fabricated by stereolithography 1 Phan Hai-Binh Bui

Session P.2: Poster Session 2
Belongs to:
Topic P: Postersession


Natural polymer based hydrogels are ideal scaffolds for tissue engineering1. Alginate based hydrogels have been widely used in tissue engineering because they are well known to be biocompatible2 and they possess many features similar to extra cellular matrix3. However, alginate hydrogels degrade very slowly and exhibit poor cell adhesion because of their lack of specific interaction with mammalian cells4. To overcome these drawbacks of alginate, several approaches are being investigated. For example, the oxidation of alginate can enhance its biodegradability, and the incorporation of specific proteins into the alginate based hydrogel can improve cellular interaction of the hydrogel. Keratin is a protein found as a main component in skin, hair, nail, hooves and horns. Keratins extracted from human hair and wool contain cell adhesive peptide sequences including RGD (arginine-glycine-aspartic acid), and LDV (leucine-aspartic acid-valine)5. The present study is aimed to prepare and to assess the properties of a novel type of hybrid hydrogel based on oxidized alginate and keratin protein extracted from wool. Oxidized alginate was synthesized via periodate oxidation of alginate. Keratin was extracted from wool by the treatment with urea, sodium metabisulfite and sodium dodecyl sulfate (SDS).The hybrid hydrogels were prepared using a sonication technique. The weight loss, protein release, FTIR, and mechanical property of the hydrogels were carried out. The results demonstrated that the composition of the hydrogels had a significant effect on their physical properties. Osteoblast-like MG-63 cells were grown on the hydrogels. Cell viability on the different hydrogels was compared by calcein fluorescent staining. The results indicated that the oxidized alginate/keratin hydrogels supported cell attachment and proliferation. The results proved that such novel hybrid hydrogels might be tuned to obtain materials suitable for tissue engineering applications.

Speaker:
Supachai Reakasame
Friedrich-Alexander-Universität Erlangen-Nürnberg
Additional Authors:
  • Felix Künzel
    Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
  • Prof. Aldo R. Boccaccini
    Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)