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Oral Poster

Dual setting system – characterization of PEG-based-hydrogel/brushite composites for biomedical application

Tuesday (09.05.2017)
18:18 - 18:21
Part of:
18:00 Oral Poster Fibrinogen Adsorption and Network Formation on Melt Drawn Isotactic Polybutene-1 Thin Films 1 Xiaoyuan Zhang
18:03 Oral Poster Characterization of biomaterials using AFM based fast nanoscale imaging and quantitative nanomechanical techniques 1 Dr. Tanja Neumann
18:06 Oral Poster Hydrothermal conversion of porous Ca carbonate biominerals into bioactive Ca phosphate materials: towards antibiotic and antiosteoporotic bone graft substitutes 1 Dr. Ingo Sethmann
18:09 Oral Poster Study on the retarding effect of phytic acid on the hydration of a brushite cement 1 Dr. Katrin Hurle
18:12 Oral Poster Synthesis of hollow mesoporous bioactive glass nanoparticles with uniform size and shape 1 Kai Zheng
18:15 Oral Poster Systematic post-operative clinical assessment of lumbar ventrolateral vertebroplasty in the large animal model sheep using a minimally-invasive approach 1 Francesca Gunnella
18:18 Oral Poster Dual setting system – characterization of PEG-based-hydrogel/brushite composites for biomedical application 0 Michaela Rödel
18:21 Oral Poster The effect of HAc etching on the degradation behaviour of Mg-5Gd 1 Dr. Frank Feyerabend
18:24 Oral Poster Degradation behavior of as cast and powder metallurgy processed Mg-Ca alloys 0 Dipl.-Ing. Eshwara Phani Shubhakar Nidadavolu
18:27 Oral Poster Bio-inspired high-performance green biopolymer fibers 0 Dr. Hendrik Bargel
18:30 Oral Poster Diatom Biosilica for Catalytic and Adsorptive Applications 1 Cathleen Fischer
18:33 Oral Poster Gallotannin polyphenol enhancement of biomimetic enzymatic hydrogel mineralization 1 Dr. Timothy E.L. Douglas
18:36 Oral Poster Starch in textile application: Modification, processing and product development 1 Pavan Kumar Manvi
18:39 Oral Poster Recombinant Spider Silk Proteins Used as Biomedical Coating Material 1 Christian Borkner
18:42 Oral Poster Effects of cross-linking modifications on Collagen: a preliminary biological evaluation 1 Dr. Mattia Vacchini
18:45 Oral Poster Endothelialization of polymethylpentene fibers as a step towards patient-specific medical devices 1 M.Sc. Annika Wenz
18:48 Oral Poster Hybrid poly-lactide/gelatin electrospun scaffolds with controlled hydrophilicity and wettability. 1 Germano Piccirillo
18:51 Oral Poster Funktion and structure - Combined optical functionality and specific bio-interaction for multifunctional biomedical materials 1 Dr. Tina Sabel
18:57 Oral Poster Bacterial adhesion to PEEK compared to exemplary dental ceramic, metallic and composite materials 1 Dr. Lutz Scheideler
19:00 Oral Poster Attachment of Nanoparticle Drug-Release Systems on Shish-Kebab structured Poly(?-Caprolactone) Nanofibers 1 Dominik de Cassan
19:06 Oral Poster Improved Nanofleeces for Cell Culture Applications 1 Tobias Kürbitz

Session P.1: Oral Poster Session 1
Belongs to:
Topic P: Postersession

More than 25 years ago, Mirtchi and Lemaître discovered brushite cements and were the pioneers in the development of this biocompatible calcium phosphate cement system. In contrast to hydroxyapatite, brushite can be resorbed under physiological conditions at a pH-level of 7.4 [1]. Based on the idea that bone is a composite material of inorganic mineral calcium phosphate reinforced with an elastic matrix, we established a dual setting system of a degradable poly(ethylene) glycol (PEG) based-hydrogel incorporated in a brushite cement phase.

In this study, we investigated the mechanical properties and especially the compressive strength. Furthermore, the Young’s modulus of both, the pure hydrogel and the composite material, was analyzed.

The composites were produced by dissolving the monomers with a concentration of 25 wt% and 50 wt% in a 0.5 M citric acid solution. An amount of 5 wt% hydrogen peroxide solution (30 %) was added to the liquid phase. The raw powder consisted of β-tricalcium phosphate (β-TCP) and monocalcium phosphate anhydrous (MCPA) in an equimolar ratio with the addition of 5 wt% ascorbic acid as radical initiator for the polymerization. After mixing, the cement setting reaction and the polymeric gelation were initiated simultaneously. The samples were fabricated in silicone molds and stored in phosphate buffered saline with a pH of 7.4.

We demonstrated extremely flexible and ductile specimens with a homogenous phase composition of the hydrogel in the cement matrix. Though the polymeric content was doubled from 25 wt% to 50 wt%, no difference in stress could be observed. With the set inorganic phase, a network of crystals was formed that gave a certain stability to the system. This also explained the increase of Young’s modulus up to 150-300 kPa in comparison to the pure hydrogels with 25-30 kPa. Additionally, XRD-measurements were performed where we could notice an influence of the polymeric matrix on the conversion from β-TCP and MCPA to brushite. Investigations concerning the compressive strength of the composites showed a more ductile behavior with the addition of high-molecular weight PEG-based hydrogels. Furthermore, the samples relaxed into the original shape after removal of the force.

Michaela Rödel
Universitätsklinikum Würzburg
Additional Authors:
  • Dr. Jörg Teßmar
    Universitätsklinikum Würzburg
  • Prof. Dr. Uwe Gbureck
    Universitätsklinikum Würzburg
  • Prof. Dr. Jürgen Groll
    Universitätsklinikum Würzburg