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Oral Poster

Synthesis of hollow mesoporous bioactive glass nanoparticles with uniform size and shape

Tuesday (09.05.2017)
18:12 - 18:15
Part of:
18:00 Oral Poster Fibrinogen Adsorption and Network Formation on Melt Drawn Isotactic Polybutene-1 Thin Films 1 Xiaoyuan Zhang
18:03 Oral Poster Characterization of biomaterials using AFM based fast nanoscale imaging and quantitative nanomechanical techniques 1 Dr. Tanja Neumann
18:06 Oral Poster Hydrothermal conversion of porous Ca carbonate biominerals into bioactive Ca phosphate materials: towards antibiotic and antiosteoporotic bone graft substitutes 1 Dr. Ingo Sethmann
18:09 Oral Poster Study on the retarding effect of phytic acid on the hydration of a brushite cement 1 Dr. Katrin Hurle
18:12 Oral Poster Synthesis of hollow mesoporous bioactive glass nanoparticles with uniform size and shape 1 Kai Zheng
18:15 Oral Poster Systematic post-operative clinical assessment of lumbar ventrolateral vertebroplasty in the large animal model sheep using a minimally-invasive approach 1 Francesca Gunnella
18:18 Oral Poster Dual setting system – characterization of PEG-based-hydrogel/brushite composites for biomedical application 0 Michaela Rödel
18:21 Oral Poster The effect of HAc etching on the degradation behaviour of Mg-5Gd 1 Dr. Frank Feyerabend
18:24 Oral Poster Degradation behavior of as cast and powder metallurgy processed Mg-Ca alloys 0 Dipl.-Ing. Eshwara Phani Shubhakar Nidadavolu
18:27 Oral Poster Bio-inspired high-performance green biopolymer fibers 0 Dr. Hendrik Bargel
18:30 Oral Poster Diatom Biosilica for Catalytic and Adsorptive Applications 1 Cathleen Fischer
18:33 Oral Poster Gallotannin polyphenol enhancement of biomimetic enzymatic hydrogel mineralization 1 Dr. Timothy E.L. Douglas
18:36 Oral Poster Starch in textile application: Modification, processing and product development 1 Pavan Kumar Manvi
18:39 Oral Poster Recombinant Spider Silk Proteins Used as Biomedical Coating Material 1 Christian Borkner
18:42 Oral Poster Effects of cross-linking modifications on Collagen: a preliminary biological evaluation 1 Dr. Mattia Vacchini
18:45 Oral Poster Endothelialization of polymethylpentene fibers as a step towards patient-specific medical devices 1 M.Sc. Annika Wenz
18:48 Oral Poster Hybrid poly-lactide/gelatin electrospun scaffolds with controlled hydrophilicity and wettability. 1 Germano Piccirillo
18:51 Oral Poster Funktion and structure - Combined optical functionality and specific bio-interaction for multifunctional biomedical materials 1 Dr. Tina Sabel
18:57 Oral Poster Bacterial adhesion to PEEK compared to exemplary dental ceramic, metallic and composite materials 1 Dr. Lutz Scheideler
19:00 Oral Poster Attachment of Nanoparticle Drug-Release Systems on Shish-Kebab structured Poly(?-Caprolactone) Nanofibers 1 Dominik de Cassan
19:06 Oral Poster Improved Nanofleeces for Cell Culture Applications 1 Tobias Kürbitz

Session P.1: Oral Poster Session 1
Belongs to:
Topic P: Postersession

Bioactive glasses (BG) have emerged as fascinating materials for bone regeneration, owing to their unique properties of bone-bonding, osteogenesis and angiogenesis potential. However, BG still suffer from the limitation of being not able to induce rapid bone regeneration and vascularization. The integration of biomolecules that can accelerate osteogenesis and angiogenesis with BG is thus an auspicious strategy towards more efficient bone regeneration. Hollow mesoporous nanoparticles are attractive materials for drug delivery, due to their morphological characteristics. Hollow mesoporous bioactive glass nanoparticles (HMBGN) are therefore considered to be attractive carriers of biomolecules for bone regeneration. However, the synthesis of HMBGN is still challenging. HMBGN can be synthesized by using soft templates through sol-gel routine, but the synthesized HMBGN mostly exhibit inhomogeneous shape and size. In this study, we developed a multi-step process to synthesize HMBGN with uniform shape and size. Solid silica nanoparticles were synthesized firstly by using the Stöber method to serve as hard templates to assembly CTAB and silica species around them. The formed hybrid nanoparticles then underwent a selected etching process to remove the solid cores prior to the incorporation of Ca ions by soaking the etched particles in calcium salt solution. HMBGN were then achieved by heating the soaked nanoparticles. These HMBGN exhibited homogenous size and spherical shape with mesoporous shell. The particle size and shell thickness of HMBGN could be tailored by tuning the size of cores and added amount of silica precursor, respectively, while the Ca content could be tuned by changing either the concentration of soaking solution or soaking time. HMBGN exhibited a large specific surface area and pore volume, as well as showing a satisfactory apatite-forming ability. These HMBGN are therefore promising materials carrying biomolecules for bone regeneration.


Kai Zheng
Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Additional Authors:
  • Elena Boccardi
    University of Erlangen-Nuremberg
  • Dr. Preethi Balasubramanian
    University of Erlangen-Nuremberg,
  • Francesca Ciraldo
    University of Erlangen-Nuremberg
  • Prof. Dr. Aldo Boccaccini
    University of Erlangen-Nuremberg