For periodontal regeneration biomaterials can be applied in order to restore the function and stability of the periodontium. The aim of the present animal study was to evaluate the integration as well as the osteoconductive and osteoinductive properties of new designed polymeric photodynamic active biomaterials.
Materials and Methods
Two new designed polymeric biomaterials based on polyurethanmethacrylate (BioM1) and polyesterurethantrimethacrylate (BioM2), mixed with β-tricalciumphosphate and the photosensitizer mTHPC were transplanted into the Femur and Tibia of sheep. Therefore, bone lesions were drilled and filled with the respective biomaterial (test sites). The control sites were sealed with bone wax, only. Regularly, the sheep received intravenous injections with fluorochrome labels. After 9 month the animals were scarified and the transplants removed. The fixed samples were radiographically analyzed by µCT and observed by laser scanning microscopy.
The highest rate of bone formation was observed among sites treated with BioM2. For both materials identical numbers in trabecular bone formation was realized. Overall, BioM1 led to an increased formation of femoral trabecular bone, whereas BioM2 induced a more compact tibial bone growth with mainly fused trabeculae.
As shown by the results, both materials present excellent osteoconductive and osteoinductive properties and are potential candidates for further periodontal regeneration studies.