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Poster Presentation

In vivo performance of polymeric photodynamic active biomaterials for periodontal regeneration

Sunday (01.01.2040)
00:00 - 08:17
Part of:
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- Poster Presentation Impact of chloride ions on apatite mineralisation on Bioglass® 45S5 0 Juliane Brandt-Slowik
- Poster Presentation In vivo performance of polymeric photodynamic active biomaterials for periodontal regeneration 1 Dr. Stefan Kranz
- Poster Presentation Adjusted material-cell interaction using engineered spider silk proteins 1 Vanessa Trossmann
- Poster Presentation Cellular interactions with extruded protein nanofibers 1 Naiana Suter
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Session P.2: Poster Session 2
Belongs to:
Topic P: Postersession


For periodontal regeneration biomaterials can be applied in order to restore the function and stability of the periodontium. The aim of the present animal study was to evaluate the integration as well as the osteoconductive and osteoinductive properties of new designed polymeric photodynamic active biomaterials.

Materials and Methods

Two new designed polymeric biomaterials based on polyurethanmethacrylate (BioM1) and polyesterurethantrimethacrylate (BioM2), mixed with β-tricalciumphosphate and the photosensitizer mTHPC were transplanted into the Femur and Tibia of sheep. Therefore, bone lesions were drilled and filled with the respective biomaterial (test sites). The control sites were sealed with bone wax, only. Regularly, the sheep received intravenous injections with fluorochrome labels. After 9 month the animals were scarified and the transplants removed. The fixed samples were radiographically analyzed by µCT and observed by laser scanning microscopy.


The highest rate of bone formation was observed among sites treated with BioM2. For both materials identical numbers in trabecular bone formation was realized. Overall, BioM1 led to an increased formation of femoral trabecular bone, whereas BioM2 induced a more compact tibial bone growth with mainly fused trabeculae.


As shown by the results, both materials present excellent osteoconductive and osteoinductive properties and are potential candidates for further periodontal regeneration studies.


Dr. Stefan Kranz
University Hospital Jena
Additional Authors:
  • Micheal Durkalets
    University Hospital Jena
  • Andrea Voelpel
    University Hospital Jena
  • Dr. Andre Guellmar
    University Hospital Jena
  • Dr. Albrecht Berg
    Innovent e.V.
  • Prof. Dr. Volker Albrecht
    biolitec GmbH
  • Prof. Dr. Bernd Sigusch
    University Hospital Jena