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Oral Poster

Study on the retarding effect of phytic acid on the hydration of a brushite cement

Tuesday (09.05.2017)
18:09 - 18:12
Part of:
18:00 Oral Poster Fibrinogen Adsorption and Network Formation on Melt Drawn Isotactic Polybutene-1 Thin Films 1 Xiaoyuan Zhang
18:03 Oral Poster Characterization of biomaterials using AFM based fast nanoscale imaging and quantitative nanomechanical techniques 1 Dr. Tanja Neumann
18:06 Oral Poster Hydrothermal conversion of porous Ca carbonate biominerals into bioactive Ca phosphate materials: towards antibiotic and antiosteoporotic bone graft substitutes 1 Dr. Ingo Sethmann
18:09 Oral Poster Study on the retarding effect of phytic acid on the hydration of a brushite cement 1 Dr. Katrin Hurle
18:12 Oral Poster Synthesis of hollow mesoporous bioactive glass nanoparticles with uniform size and shape 1 Kai Zheng
18:15 Oral Poster Systematic post-operative clinical assessment of lumbar ventrolateral vertebroplasty in the large animal model sheep using a minimally-invasive approach 1 Francesca Gunnella
18:18 Oral Poster Dual setting system – characterization of PEG-based-hydrogel/brushite composites for biomedical application 0 Michaela Rödel
18:21 Oral Poster The effect of HAc etching on the degradation behaviour of Mg-5Gd 1 Dr. Frank Feyerabend
18:24 Oral Poster Degradation behavior of as cast and powder metallurgy processed Mg-Ca alloys 0 Dipl.-Ing. Eshwara Phani Shubhakar Nidadavolu
18:27 Oral Poster Bio-inspired high-performance green biopolymer fibers 0 Dr. Hendrik Bargel
18:30 Oral Poster Diatom Biosilica for Catalytic and Adsorptive Applications 1 Cathleen Fischer
18:33 Oral Poster Gallotannin polyphenol enhancement of biomimetic enzymatic hydrogel mineralization 1 Dr. Timothy E.L. Douglas
18:36 Oral Poster Starch in textile application: Modification, processing and product development 1 Pavan Kumar Manvi
18:39 Oral Poster Recombinant Spider Silk Proteins Used as Biomedical Coating Material 1 Christian Borkner
18:42 Oral Poster Effects of cross-linking modifications on Collagen: a preliminary biological evaluation 1 Dr. Mattia Vacchini
18:45 Oral Poster Endothelialization of polymethylpentene fibers as a step towards patient-specific medical devices 1 M.Sc. Annika Wenz
18:48 Oral Poster Hybrid poly-lactide/gelatin electrospun scaffolds with controlled hydrophilicity and wettability. 1 Germano Piccirillo
18:51 Oral Poster Funktion and structure - Combined optical functionality and specific bio-interaction for multifunctional biomedical materials 1 Dr. Tina Sabel
18:57 Oral Poster Bacterial adhesion to PEEK compared to exemplary dental ceramic, metallic and composite materials 1 Dr. Lutz Scheideler
19:00 Oral Poster Attachment of Nanoparticle Drug-Release Systems on Shish-Kebab structured Poly(?-Caprolactone) Nanofibers 1 Dominik de Cassan
19:06 Oral Poster Improved Nanofleeces for Cell Culture Applications 1 Tobias Kürbitz

Session P.1: Oral Poster Session 1
Belongs to:
Topic P: Postersession

Hydration of calcium phosphates under acidic conditions results in brushite (CaHPO4*2H2O) formation. One example for a brushite forming cement is the addition of H3PO4 to β-tricalcium phosphate (β-TCP), which reacts according to (1).

β-Ca3(PO4)2 + H3PO4 + 6 H2O → 3 CaHPO4*2H2O (1)

As this reaction proceeds very rapidly, retardation is necessary to obtain clinically acceptable setting times. Phytic acid (IP6), C6H6(OPO3H2)6, is a possible additive to achieve this. IP6 is additionally expected to improve the rheological performance of the cement pastes and the mechanical properties of the hardened cements.

In order to evaluate the general feasibility of creating brushite cement formulations modified with IP6, the hydration of such cements was systematically investigated by isothermal calorimetry and in-situ XRD. Crystalline β-TCP was mixed with H3PO4 solution of a proper concentration to achieve a molar ratio of β-TCP:H3PO4 = 1:1. The water to cement ratio was 0.5. IP6 concentrations of 5, 10, 12.5, 15 and 20 wt.% related to the β-TCP content were selected. Measurements were performed at 23 °C.

Calorimetry measurements proved a generally increasing retardation effect of IP6 with increasing concentration. By increasing the IP6 concentration from 10 to 12.5 wt.%, the sharp calorimetry peak indicating a rapid reaction disappears in favour of a broad heat flow event, indicating a slower and continuous reaction. In all cases, β-TCP reacted completely or at least nearly completely. While hydration of samples with 5 wt.% IP6 addition resulted in only brushite, higher IP6 concentrations led to mixtures of monetite and brushite.

Consequently, the studies proved that IP6 effectively retards β-TCP hydration and affects composition of the hardened cement, but does not impede hydration. Hence creation of IP6 modified brushite cement formulations is generally feasible.


Dr. Katrin Hurle
Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Additional Authors:
  • Prof. Dr. Jürgen Neubauer
    Friedrich-Alexander-Universität Erlangen-Nürnberg
  • Prof. Dr. Friedlinde Götz-Neunhoeffer
    Friedrich-Alexander-Universität Erlangen-Nuernberg