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Poster Presentation

Microfibers and Nanoparticles with Controlled Dimensions of a Hyaluronic Acid Derivative

Part of:
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- Poster Presentation PLA based CaCO3 composite fibers for textile scaffolds in hard tissue regeneration 1 Dr.-Ing. Claudia Hinüber
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- Poster Presentation Development and Characterization of Hybrid Hydrogel Based on Oxidized Alginate and Keratin for Tissue Engineering Applications 0 Supachai Reakasame
- Poster Presentation Nir Laser-responsive Folate-targeted Gold Nanorods As Efficient theranostic tool for Osteosarcoma Treatment 1 Ph.D. Nicol? Mauro
- Poster Presentation Mechanical properties of recent CAD/CAM polymer materials 1 Sebastian Spintzyk
- Poster Presentation Multilayers of Nanoparticles with Alginate, Chondroitin sulfate and Hyaluronic acid for graded implants 1 Steffen Sydow
- Poster Presentation Design of drug eluting ophthalmic lenses through a multi-layer approach 1 Dr. Ana Topete
- Poster Presentation Drug loaded silicon based soft contact lenses: effect of terminal sterilization methods on their performance 1 Andreia Sofia Oliveira
- Poster Presentation Investigating the compressibility of spray dried alumina-zirconia granules for use in orthopaedics - an easy to use and fast method 1 Dr. Ranko Adjiski
- Poster Presentation Biochemical modification of extruded protein nanofibers 1 Karsten Stapelfeldt
- Poster Presentation Microfibers and Nanoparticles with Controlled Dimensions of a Hyaluronic Acid Derivative 1 Ph.D. Calogero Fiorica
- Poster Presentation Modeling the Viscosity of Silicone Rubber During High-Speed Infrared Curing 1 Jan Stieghorst
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- Poster Presentation New crosslinking diluents for dental materials 1 Prof. Dr. Norbert Moszner
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- Poster Presentation Adjusted material-cell interaction using engineered spider silk proteins 1 Vanessa Trossmann
- Poster Presentation Cellular interactions with extruded protein nanofibers 1 Naiana Suter
- Poster Presentation Antimicrobial efficacy of strontium and zinc glasses and glass ionomer cements against clinically relevant bacteria 0 Hawshan Mustafa
- Poster Presentation Mechanical properties of water-soluble polyvinyl alcohol parts fabricated by fused deposition modelling 1 Jochen Kuttig
- Poster Presentation Corrosion behavior of dental CoCr alloys made by different digital workflow processes compared to cast CoCr alloys 0 Christine Schille
- Poster Presentation Mechanical properties of biocompatible polymer-based resin for dental applications fabricated by stereolithography 1 Phan Hai-Binh Bui

Session P.2: Poster Session 2
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Topic P: Postersession

Microfluidics is defined as the technology that deals with the precise control and manipulation of small quantities of fluids constrained in micro-channels of small cross-sectional dimensions [1].

Microfluidics has recently emerged as a very promising route for the production of polymeric fibers at the micro and nanoscale, providing a fine control over fiber shape, size, chemical anisotropy and biological activity [2]. Furthermore, the ability to manipulate nanoliter volumes of liquid and to control mixing and reaction precisely, opens up the possibility of creating smart targeted drug delivery systems as nanoparticles, especially with uniform and narrow size distribution [3].

This work describes the versatility of an amphiphilic hyaluronic acid derivative (HA-EDA-C18) [4] to produce well-defined microfibers and nanoparticles based on self-assembly of its polymer chains, by using microfluidic technique. In particular, two HA-EDA-C18 derivatives with different molecular weight have been synthesized and characterized by SEC and rheological analyses. HA-EDA-C18 with major molecular weight (~322000 Da) has been employed to produce full and hollow microfibers. In particular, full microfibers have been obtained with different size changing microfluidic parameters and chip. Possibility to perform biofunctionalization of fibers was demonstrated by chemical and physical fiber functionalization with cy-RGD and fibronectin respectively, and the adhesive properties have been assayed on Human Umbilical Vein Cells (HUVECs). Hollow microfibers were produced using a 3D flow focusing chip. The potentiality to cell encapsulation has been evaluated on primary bovine chondrocytes.

HA-EDA-C18 with minor molecular weight (~125000 Da) has been employed to prepare nanoparticles with controlled dimension. These have been obtained by monitoring the nano-precipitation in DPBS pH 7.4 into Micromixer chip, using a different flow rate ratio between the inner and external channels and nanoparticles obtained were finally characterized by dynamic light scattering and TEM.


Ph.D. Calogero Fiorica
University of Palermo
Additional Authors:
  • Dr. Stefano Agnello
    University of Palermo
  • Dr. Flavia Bongiovì
    University of Palermo
  • Prof. Fabio Salvatore Palumbo
    University of Palermo
  • Prof. Giovanna Pitarresi
    University of Palermo
  • Prof. Gaetano Giammona
    University of Palermo